Cart
sales@molnova.com
Home - Products - NF-κB - NOD - NLRP3 agonist 1

NLRP3 agonist 1

CAS No. 2454019-69-1

NLRP3 agonist 1( —— )

Catalog No. M37305 CAS No. 2454019-69-1

NLRP3 agonist 1 (compound 23) is a potent, orally active agent that activates Caspase-1 enzyme, resulting in the cleavage of proinflammatory cytokines pro-IL-1β and pro-IL-18 into their active forms .

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    NLRP3 agonist 1
  • Note
    Research use only, not for human use.
  • Brief Description
    NLRP3 agonist 1 (compound 23) is a potent, orally active agent that activates Caspase-1 enzyme, resulting in the cleavage of proinflammatory cytokines pro-IL-1β and pro-IL-18 into their active forms .
  • Description
    NLRP3 agonist 1 (compound 23) is a potent and orally active NLRP3 agonist. NLRP3 agonist 1 can activate the enzyme Caspase-1 to cleave pro-IL-1β and pro-IL-18 proinflammatory cytokines into their mature forms.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    NF-κB
  • Target
    NOD
  • Recptor
    NOD-like Receptor (NLR)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2454019-69-1
  • Formula Weight
    280.33
  • Molecular Formula
    C15H16N6
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (356.72 mM; Ultrasonic (<80°C)
  • SMILES
    N=1NC=CC1C=2C=CC3=C(N=C(N=C3NC4(C)CC4)N)C2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. O' Donovan DH, et, al. Discovery and characterisation of quinazolines and 8-Azaquinazolines as NLRP3 agonists with oral bioavailability in mice. Bioorg Med Chem Lett. 2023 Oct 12:96:129518.?
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • NP3-146

    NP3-146 (NLRP3-IN-5) is an inflammasome NLRP3 inhibitor with potential anti-inflammatory activity for the study of autoimmune diseases.

  • Nodinitib-1

    A potent and selective NOD1 inhibitor with IC50 of 0.56 uM.

  • Emlenoflast

    Emlenoflast is a potent and selective inhibitor of NLRP3 inflammasome.

Sign In Join Free